![]() Older people who don’t get enough vitamin B12 may be at higher risk for anemia and infections. It may cause nerve damage, and studies show low vitamin B12 levels may be a risk factor for problems in cognitive function such as dementia and psychosis. Left untreated, a vitamin B12 deficiency may lead to decreased motor function, including balance problems, tremors, an increased risk of falling, and numbness or tingling in your extremities.Ĭhronic vitamin B12 deficiency in blood levels can dramatically affect the brain and nervous system. Chronic deficiency may result in weight loss, loss of appetite, and digestive issues. These may include confusion, depression, difficulty recalling or remembering information, and tiredness. When you don’t get enough vitamin B12, you may experience deficiency symptoms. Additional research indicates low levels of vitamin B12 may increase the risk of macular degeneration. Studies show low vitamin B12 levels have been linked with osteoporosis. Vitamin B12 may also play a part in bone and vision health. That’s why you may feel fatigued or dizzy when you have a deficiency. Vitamin B12 helps to create and reproduce blood cells and is also involved in producing energy. This amino acid has been linked to cognitive decline in Alzheimer’s and Parkinson’s disease. Vitamin B12 helps to metabolize an amino acid known as homocysteine. Vitamin B12 is particularly important because it plays a role in brain function, metabolism, nerve cells, and blood health. ![]() It is only contraindicated in patients with inability to take oral medication or who present vomiting or diarrhea.It’s no secret that getting your vitamins and nutrients is key to staying healthy. The oral treatment avoids the complications inherent to the injection and also relative contraindications, such as anticoagulation. Adverse effects to overdosage of vitamin B12 have not been reported. Thus, if the daily needs of B12 are approximately 2 μg, administering oral supplements at high doses (1-2 mg) once a day can achieve a sufficient amount to ensure the values and filling of the tissue stores through passive intestinal absorption. Several studies have shown that the small percentage (1-2%) of vitamin that is passively absorbed in the intestine could be sufficient to achieve, with high doses of vitamin B12, adequate concentrations in the body, even in cases of absence of IF by pernicious anemia or gastrectomy, achlorhydria, malabsorption or lack of integrity of the terminal ileum. There is abundant accumulated evidence that the replacement of B12 can be carried out effectively orally. ![]() This treatment does not usually produce adverse effects, but it involves repeated visits, discomforts and risks in relation to the use of the parenteral route. The most usual regimen consists of daily doses of 1,000 μg for one week, followed by weekly injections for 4 weeks and, then, monthly. The administration of vitamin B12 to correct or prevent the deficiency is usually for life, and has traditionally been prescribed in the form of intramuscular injections. Vitamin B12 passes into the bloodstream bound to transcobalamin II, which transports it to the liver and other areas of the body. The B12-FI complex binds to the ileal cell receptors and is absorbed by endocytosis. It is absorbed in the distal ileum, after passing through the small intestine linked to the intrinsic factor (IF), a protein synthesized in the parietal cells of the gastric fundus. The vitamin ingested in the diet is separated from animal proteins by pepsin and gastric hydrochloric acid, joining haptocorrin, a protein of salivary origin, which is dissociated in the duodenum by the action of pancreatic proteases. ![]() The human organism is not able to synthesize it and must obtain it from the diet, mainly from foods of animal origin (meat, milk and derivatives, eggs, fish). Vitamin B12 or cobalamin plays a key role as a coenzyme in DNA synthesis and cell maturation, as well as in the synthesis of neuronal lipids. The daily dose of 1 mg (1000 mcg) oral cobalamin has shown good long-term results the possibility of intermittent maintenance guidelines is investigated. Is It OK To Take 1000 mcg of Vitamin B12 a Day? ![]()
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